I had actually given up on Assetto Corsa after struggling with Proton tweaks etc in Steam and had got rFactor 2 running instead, but rF2 was still having issues with many older tracks not loading.
Lutris' big claim to fame (for me anyway) is that there are some tried and tested scripts available on their site (one button click to install) which seems to essentially sandbox a host of tweaks in one go that will work for each game. So yes it will take a bit more space as it installs WINE, MS .Net, etc as needed for each game, but it is a balance that works.
Assetta Corsa is over 10 GB in its download and is a highly detailed racing sim. Absolutely everything works except the force feedback for my cheap Speedlink racing wheel. But the wheel drives fine and I aim to replace it with a Logitech G29 which has a driver to support FFB. I have not yet tested out the online racing part but so far all looks good.
Lutris did initially give me errors on the install of the game but I then saw my Nvidia drivers were not the latest version (separate update from the normal package updates for major version releases) and I fully deleted my Steam version of AC. After that the install took over an hour but it did its magic all unattended.
More info on Lutris at About Lutris
Play all your games on Linux. Lutris is an Open Source gaming platform for Linux. It installs and launches games so you can start playing without the hassle of setting up your game. Get your games from GOG, Steam, Battle.net, Origin, Uplay and many other sources running on any Linux powered gaming machine.